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Recent studies using a neuroblastoma cell line SH-SY5Y and hippocampal neurons revealed that metformin can inhibit A-induced apoptosis by decreasing ROS and reversing autophagy defects ( Figure 1

Immunometabolism and natural killer cell responses

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Scientists are developing drugs that act on two or even three different receptors to create a more powerful effect on appetite and metabolism

PMID: 15861116 Hinterberger JW, Kintzi HE (1994): Phentolamine reversal of epinephrine-induced digital vasospasm